Empirical Health is dedicated to redefining the future of cardiovascular health by leveraging cutting-edge AI and comprehensive biomarker analytics to foresee and prevent heart disease before it manifests. Our vision is to create a world where heart attacks are no longer a leading cause of mortality through early detection, precise risk prediction, and fully personalized healthcare interventions.
At Empirical Health, we harness the power of advanced machine learning, wearable technology integration, and deep health analytics to empower individuals with knowledge and actionable insights designed to extend and enhance quality of life. By combining a holistic view of physical and mental health, we pioneer an era of truly proactive primary care that transforms patient engagement and outcomes on a scalable level.
Our mission drives us to build an inclusive, data-driven ecosystem that not only improves individual health trajectories but revolutionizes how healthcare is delivered—making preventive and personalized care accessible and effective across diverse populations and healthcare systems. This is healthcare reimagined for a longer, healthier future.
Our Review
We've been keeping an eye on Empirical Health since they emerged from Y Combinator in 2022, and honestly? Their approach to heart disease prevention caught our attention immediately. This isn't just another wellness startup throwing around buzzwords — they're tackling the leading cause of death in America with some seriously impressive tech.
What Makes Them Different
Most health companies either do basic blood panels or offer generic wellness advice. Empirical Health does both, but way better. Their heart health panel tests 85+ biomarkers (including hard-to-get ones like ApoB and Lp(a)) for $190, then uses AI to predict your cardiovascular risk up to 30 years out. That's the kind of forward-thinking we rarely see in healthcare.
The founders bring serious credibility too — Dr. Raquel Rodriguez Martinez from UCSF and Kaiser paired with Brandon Ballinger, who previously co-founded Cardiogram and worked on ML at Google. It's exactly the physician-engineer combo you'd want building something this complex.
The Tech That Impressed Us
Their "Radar" health scoring system is genuinely clever. It pulls data from your lab results, wearables like Apple Watch, and health questionnaires to create a composite score that weighs heart and mental health heavily. We love that they're not ignoring the mental health piece — depression screening through PHQ-9 shows they understand health holistically.
The mobile app integration feels seamless too. You can track biomarker trends over time, connect multiple wearable devices, and get personalized action plans all in one place. It's the kind of comprehensive platform we wish existed years ago.
Who Should Consider This
If you're someone who wants to get ahead of heart disease rather than react to it, Empirical Health makes a lot of sense. Their virtual primary care platform is now in-network with major insurers across 30 states, which means this isn't just for the wealthy early-adopter crowd anymore.
We're particularly excited about their proactive primary care approach. With the massive shortage of primary care doctors, scaling quality preventive care through AI and virtual visits could be a game-changer for millions of people stuck in reactive healthcare cycles.
Features
Heart Health Program with 85+ biomarkers including ApoB, Lp(a), hs-CRP, cholesterol, triglycerides
AI-Driven Risk Assessment integrating labs, wearable data, and health questionnaires
Personalized risk prediction and tailored action plans (nutrition, medication, exercise)
Proactive Primary Care virtual platform with preventive visits, chronic disease management, prescriptions, referrals
Mobile app for biomarker tracking, wearable device integration, health trend monitoring
FAQs
Ploy was founded in 2024.
Proactive primary care that scales with AI. YC S23.
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